Lifirafenib maleate - CAS 1854985-74-2

Lifirafenib (BGB-283) maleate, a novel inhibitor targeting both Raf Kinase and EGFR, exhibits potent activity with IC50 values of 23 nM and 29 nM against recombinant BRaf V600E and EGFR, respectively [1].

Raf, EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, MAPK, Angiogenesis

1854985-74-2

C62H46F6N8O18

1305.06

OC(/C=C\C(O)=O)=O.[H][C@@]12[C@@H](C(NC3=C4)=NC3=CC=C4C(F)(F)F)[C@]1([H])C5=CC(OC6=C7C(NC=C6)=NC(CC7)=O)=CC=C5O2.OC(/C=C\C(O)=O)=O.[H][C@@]89[C@@H](C(NC%10=C%11)=NC%10=CC=C%11C(F)(F)F)[C@]8([H])C%12=CC(OC%13=C%14C(NC=C%13)=NC(CC%14)=O)=CC=C%12O9.OC(/C=C\C(O)=O)=O

-20°C

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