Linarin - CAS 480-36-4

1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.

PKA, Apoptosis, Cholinesterase (ChE), HIV Protease, Influenza Virus, Antibacterial, TNF

Proteases/Proteasome, Tyrosine Kinase/Adaptors, Neuroscience, Microbiology/Virology, Apoptosis

440

0.9899

C28H32O14

592.55

COc1ccc(cc1)-c1cc(=O)c2c(O)cc(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)cc2o1

-20°C

Ice Packs

Natural Product