Linvemastat - CAS 2389060-50-6

Linvemastat (Compound FC-4) is an orally active MMP-12 inhibitor with an IC50 of less than 10 nM and demonstrates high selectivity over MMP-1, -2, -3, -7, -9, -10, and -14. It significantly reduces lung fibrosis in a mouse model of bleomycin-induced unilateral pulmonary fibrosis and effectively alleviates kidney damage, interstitial inflammation, or fibrosis in a unilateral ureteral obstruction renal fibrosis model. Linvemastat is suitable for research into inflammatory diseases such as idiopathic pulmonary fibrosis (IPF), inflammatory bowel disease (IBD), and asthma.

MMP

Proteases/Proteasome

2389004

C20H17N3O4S

395.43

O=C1NC(=O)C(N1)C=2OC=CC2SC3=CC=C(OCC=4C=CN=C(C4)C)C=C3

-20°C

Ice Packs

Small Compound