Lipid U 105 - CAS 3049129-14-5

Lipid U 105, an ionizable cationic lipid (pKa = 6.65), is employed in formulating lipid nanoparticles (LNPs) for delivering circular RNA both in vitro and in vivo. These LNPs, containing lipid U 105 and circular RNA for VEGF-A, enhance VEGF-A levels, boosting the proliferation and migration of human umbilical vein endothelial cells (HUVECs) . Moreover, applying these LNPs topically accelerates wound healing in diabetic mice on a high-fat and -sugar diet.

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3049129-14-5

C53H106N2O6

867.42

O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCN(CCCN(CCO)CCO)CCCCCC(=O)OC(CCCCCCCC)CCCCCCCC

-20°C

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