LLK203 - CAS 2758090-62-7

LLK203 is a potent dual-target inhibitor of USP2/USP8 with IC50 values of 0.89 μM and 0.52 μM, respectively. It promotes ERα degradation and induces apoptosis in breast cancer MCF-7 cells, demonstrating antitumor activity in the 4T1 tumor mice model [1].

Apoptosis, DUB

Cell Cycle/Checkpoint, Ubiquitination, Apoptosis, DNA Damage/DNA Repair

2758090-62-7

C28H23N3O4S3

561.69

C(NC1=NC(=CS1)C2=CC=CC=C2)(=O)C3=C(NS(=O)(=O)C4=CC=C(C=C4)C=5SC(C)=CC5)C=C(OC)C=C3

-20°C

Ice Packs

Small Compound