LLP-3 - CAS 1453835-43-2

Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5) ) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM) . It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.

Survivin, Others

Apoptosis, Others

1453790

C32H23ClN2O4

534.99

C(#N)C1=C(C=C(NC1=O)C2=C(O)C=CC(Cl)=C2)C3=CC(OCC4=CC=CC=C4)=CC(OCC5=CC=CC=C5)=C3

-20°C

Ice Packs

Small Compound