LNS8801 - CAS 925419-55-2

LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER) . By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.

Estrogen Receptor/ERR

Endocrinology/Hormones

925362

C21H18BrNO3

412.277

BrC1=C([C@@H]2[C@]3([C@@](C=4C(N2)=CC=C(C(C)=O)C4)(C=CC3)[H])[H])C=C5C(=C1)OCO5

-20°C

Ice Packs

Small Compound