Lobaric acid - CAS 522-53-2

Lobaric acid is a depsidone metabolite isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activities. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol), inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml), inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme), and inhibits production of 12 (S) -HETE [Item No. 34570] by 12 (S) -lipoxygenase (IC50 = 28.5 μM) . In vivo, lobaric acid (250 μM) reduces lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV) .

Others, Phosphatase, Lipoxygenase, TMV

Metabolism, Immunology/Inflammation, Others

467

C25H28O8

456.48

C(CCCC)C1=C2C(OC(=O)C=3C(O2)=CC(OC)=CC3C(CCCC)=O)=CC(O)=C1C(O)=O

-20°C

Ice Packs

Small Compound