Lofepramine - CAS 23047-25-8

Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.

Others, Adrenergic Receptor, 5-HT Receptor, Norepinephrine

GPCR/G Protein, Neuroscience, Others

23014

0.9838

C26H27ClN2O

418.96

C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3

-20°C

Ice Packs

Small Compound