Lometrexol disodium - CAS 120408-07-3

Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causing detectable levels of DNA strand breaks. Lometrexol disodium exhibits anticancer effects by inhibiting the de novo synthesis of purines, causing abnormal cell proliferation, apoptosis and cell cycle arrest.

Others, Bcl-2 Family, Apoptosis, Caspase, Antifolate

Apoptosis, Proteases/Proteasome, Others, Cell Cycle/Checkpoint

120408-07-3

C21H23N5Na2O6

487.424

[Na+].[Na+].Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)Cc2c(=O)[nH]1

-20°C

Ice Packs

Small Compound