Lomibuvir - CAS 1026785-55-6

Lomibuvir (VCH-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1].

HCV Protease, DNA/RNA Synthesis

Proteases/Proteasome, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

1026724

>99.99%

C25H35NO4S

445.61

CC1CCC(CC1)C(=O)N(C1CCC(O)CC1)c1cc(sc1C(O)=O)C#CC(C)(C)C

-20°C

Ice Packs

Small Compound