Losartan Carboxylic Acid - CAS 124750-92-1

Losartan Carboxylic Acid (E-3174), a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), produces a depressor response and vasodilatation. As a metabolite of losartan, it is more potent than losartan in blocking angiotensin II-induced responses in vascular smooth muscle cells.

RAAS, Drug Metabolite

Endocrinology/Hormones, Metabolism

124657

0.9928

C22H21ClN6O2

436.89

C(N1C(CCCC)=NC(Cl)=C1C(O)=O)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

-20°C

Ice Packs

Small Compound