LRK-4189 - CAS 3063346-83-5

LRK-4189 is an orally active, selective PIP4K2C PROTAC degrader with a DC50 <500 nM in MOLT-4 cells. It induces endogenous apoptosis and activates the interferon signaling pathway, exhibiting antitumor activity against microsatellite stable (MSS) colorectal cancer (CRC) cells.

PROTACs

PROTAC

3063258

C43H49F2N9O4

793.9

FC=1C(C2=CC(=CC=C2)N3C(=O)C=CC=C3)=NC(N[C@@H]4CC[C@@H](NC(=O)[C@@H]5CC[C@H](CC5)N6CCN(CC6)C7=C(F)C=C(N[C@@H]8C(=O)NC(=O)CC8)C=C7)CC4)=NC1

-20°C

Ice Packs

PROTAC