LSD1-IN-20 - CAS 1239589-91-3

Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, with IC50 of 0.51 and 1.60 μM, respectively, at 72 h.

Histone Demethylase, Histone Methyltransferase

Chromatin/Epigenetic

1239495

0.9957

C27H38N6O2

478.63

N(C=1C2=C(N=C(NCCCN(C)C)N1)C=C(OC)C(OC)=C2)C3CCN(CC4=CC=CC=C4)CC3

-20°C

Ice Packs

Small Compound