LT175 - CAS 862901-87-9

LT175, a dual PPARα/γ ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARγ with EC50 values of 0.22 μm for hPPARα, 0.26 μm for mPPARα, and 0.48 μm for hPPARγ. LT175 specifically interacts with PPARγ, influencing the recruitment of coregulators, such as the cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), within a hydrophobic region known as the diphenyl pocket [1].

Others, PPAR

Others, Metabolism, DNA Damage/DNA Repair

862901-87-9

C21H18O3

318.37

OC(=O)[C@H](Cc1ccccc1)Oc1ccc(cc1)-c1ccccc1

-20°C

Ice Packs

Small Compound