LW1564 - CAS 2668337-39-9

LW1564 is an HIF-1α inhibitor with an IC50 of 1.2 μM in HepG2 cells. It suppresses mitochondrial respiration, reduces ATP production, and stimulates HIF-1α degradation, thereby inhibiting the proliferation of various cancer cells with a GI50 ranging from 0.4 to 4.6 μM. Additionally, LW1564 activates the AMPK signaling pathway and inhibits lipid synthesis. In HepG2 xenograft mouse models, LW1564 demonstrates antitumor activity.

AMPK, HIF/HIF Prolyl-Hydroxylase

PI3K/Akt/mTOR signaling, Metabolism, Chromatin/Epigenetic

2668289

C42H48F3N3O5

731.84

O=C(N1CCN(CC2=CC=C(C=C2)C(F)(F)F)CC1)COC3=CC=C(C=C3)C45CC6CC(CC(C(=O)N7CC8=CC(OC)=C(OC)C=C8CC7)(C6)C4)C5

-20°C

Ice Packs

Small Compound