LXY3 - CAS 1095009-44-1

LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.

Integrin

Cytoskeletal Signaling

1095009-44-1

C32H43N11O15S2

885.88

O=C1[C@]2(N(C[C@H](O)C2)C(=O)CNC(=O)[C@H](CC3=CC(N(=O)=O)=C(O)C=C3)NC(=O)CNC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](N)CSSC[C@H](C(N)=O)NC(=O)[C@H](CC(N)=O)N1)[H]

-20°C

Ice Packs

Peptide