LY 345899 - CAS 10538-99-5

LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.

DHFR, Dehydrogenase

Metabolism, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

10434

0.997

C20H21N7O7

471.42

Nc1nc2NCC3CN(C(=O)N3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

-20°C

Ice Packs

Small Compound