LY2780301 - CAS 1226801-23-5

LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Akt, Others

Others, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

1226773

C25H27F4N7O

517.52

C(CN(C)C)N1C(=NC(=C1)C2=CC(C(F)(F)F)=C(F)C=C2)C3CCN(CC3)C4=C5C(NC(=O)C5)=NC=N4

-20°C

Ice Packs

Small Compound