LY3526318 - CAS 1889218-34-1

LY3526318 is an orally active, selective TRPA1 antagonist with an IC50 of 5-6 μM. It blocks the TRPA1 channel, inhibiting pain signal transduction mediated by this channel and demonstrating analgesic activity. LY3526318 is primarily utilized in research related to chronic pain, such as diabetic peripheral neuropathic pain, chronic lower back pain, and osteoarthritis-induced pain.

TRP/TRPV Channel

Membrane transporter/Ion channel

1889183

C23H19F3N10O4

556.46

[C@@H](C(NC=1N=C(C=CC1)C=2C=NC(C(F)(F)F)=NC2)=O)(C)N3C4=C(N(C)C(=O)N(CC5=NC(C)=NO5)C4=O)N=C3

-20°C

Ice Packs

Small Compound