LYG-409 - CAS 3053857-55-6

LYG-409 is an orally active GSPT1 degrader. It demonstrates exceptional in vivo anti-tumor activity against acute myeloid leukemia and prostate cancer, with tumor growth inhibition rates (TGI) of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells by degrading GSPT1, with an IC50 of 9.50 nM and a DC50 of 7.87 nM in vitro.

Molecular Glues

PROTAC

3053796

C25H20F3N3O6

515.438

O=C(NCC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=5C=C(OC(F)(F)F)C=CC5OC4

-20°C

Ice Packs

PROTAC