LYP-IN-1 - CAS 1404436-51-6

LYP-IN-1 is a potent and highly selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP), with a Ki value of 110 nM and an IC50 of 0.259 μM. LYP-IN-1 exhibits additional selectivity against a broad range of PTPs, including SHP1 (IC50 = 5 μM) and SHP2 (IC50 = 2.5 μM) . LYP-IN-1 demonstrates strong efficacy in both T cells and mast cells, making it a valuable compound for research into autoimmune disorders and immune signaling pathways.

Phosphatase

Metabolism

1404379

0.9243

C28H20ClNO6

501.92

OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccc(OCC(=O)NC2CC2)cc1

-20°C

Ice Packs

Small Compound