Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) - CAS 1234494-75-7

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C) ) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4) .1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.

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1234412

C15H40Cl4N8

474.34

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-20°C

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Small Compound