LZ-007 - CAS 2920000-23-1

LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.

FXR

Metabolism

2919976

C27H29F3N2O5

518.53

O=C(O)C1=CC=C(OCC2CCN(CC=3C(=NOC3C(C)C)C=4C=CC=CC4OC(F)(F)F)CC2)C=C1

-20°C

Ice Packs

Small Compound