M‐89 MLL inhibitor - CAS 2446155-01-5

M‐89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM) . M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.

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2446155-01-5

C37H47N5O4S

657.87

N(C(OC)=O)[C@@H]1[C@@]([C@]2(C=3C(CN(C)C2)=CC=CC3)[C@@H]4CCN(CC5CN(C5)C6=CC=C(S(=O)(=O)C=7C=CN=CC7)C=C6)CC4)(CCC1)[H]

-20°C

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Small Compound