M04 - CAS 875158-73-9

M04 acts as a stimulator of interferon genes (STING) agonist, effectively inducing IFN reporter gene expression in HEK293T cells equipped with wild-type human STING. Its activity is specific, not affecting HEK293T cells with the R71H-G230A-R293Q (HAQ) human STING variant or mouse RAW 264.7 cells, showcasing allelic- and species-dependent effects at a concentration of 75 μM. This compound also stimulates the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs) . At 50 μM, M04 enhances human monocyte-derived dendritic cells' expression of HLA-DR (MHC class II receptor) and co-stimulatory molecules CD40, CD80, and CD86, improving T cell cross-priming in an ex vivo assay.

Others, Immunology/Inflammation related, Interleukin, STING, TNF

Others, Immunology/Inflammation, Apoptosis

875158-73-9

C18H24N2O4S3

428.58

CN(C)c1sc(nc1S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)C1CCCCC1

-20°C

Ice Packs

Small Compound