M3541 - CAS 1360628-91-6

M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage checkpoints, inhibits DNA damage repair, contributes to apoptosis, and induces death of ATM overexpressing tumor cells.

Apoptosis, ATM/ATR

PI3K/Akt/mTOR signaling, Apoptosis, DNA Damage/DNA Repair

1360531

0.9947

C23H17FN6O2

428.42

O=C1N(C=2C=3C(=CC(OC)=C(C3)C4=CN(C)N=C4)N=CC2N1C)C5=C(F)C=C(C#N)C=C5

-20°C

Ice Packs

Small Compound