M3686 - CAS 2738550-24-6

M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.

YAP

Stem Cells

2738520

C21H18F3N5O2

429.395

CN1N=C2N(C=3C(C2=N1)=CC(C(=O)N4CC[C@H](O)C4)=CC3)C5=CC=C(C(F)(F)F)C=C5

-20°C

Ice Packs

Small Compound