MAC glucuronide α-hydroxy lactone-linked SN-38 - CAS 2246380-70-9

MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a cytotoxic drug linker that maintains a stabilized lactone form, demonstrating efficacy against L540cy and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related

2246301

C50H54N6O20S

1091.06

O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@]5(OCN(C(OCC6=CC(NC(CN(C(CCN7C(=O)C=CC7=O)=O)C)=O)=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C=C6)=O)CCS(C)(=O)=O)CC

-20°C

Ice Packs

PROTAC