MAGL-IN-22 - CAS 2720674-71-3

MAGL-IN-22 (Compound 40) is a reversible, competitive, and selective inhibitor of MAGL that is capable of crossing the blood-brain barrier, with an IC50 of 0.34 μM for hMAGL. It exhibits significant antioxidant and anti-inflammatory properties, activating the Nrf2 pathway and markedly suppressing NFκB-mediated inflammation, without inducing cytotoxic effects. MAGL-IN-22 is applicable in research on neurodegenerative diseases, chronic pain, and cancer.

Nrf2, MAGL, NF-κB

Metabolism, Immunology/Inflammation, NF-κB

2720600

C22H20FNO3

365.4

O=C(NC1=CC(=CC=C1O)C=2C=CC(O)=C(F)C2)CCCC=3C=CC=CC3

-20°C

Ice Packs

Small Compound