Mal-amide-PEG8-Val-Cit-PAB-OH - CAS 2387738-43-2

Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.

ADC Linker

Antibody-drug Conjugate/ADC Related

2387738-43-2

C44H71N7O16

954.072

N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(=O)C=CC1=O)=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C2=CC=C(CO)C=C2

-20°C

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