Mal-amide-PEG8-Val-Cit-PAB-PNP - CAS 1964490-09-2

Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker comprising a maleimide group, a PEG spacer, a Val-Cit dipeptide, PAB, and a PNP carbonate. The maleimide serves as a thiol-specific covalent connector for labeling cysteine residues in proteins, whereas the PNP group acts as a highly reactive leaving group. The Val-Cit linker is cleaved by cytoplasmic peptidases.

ADC Linker

Antibody-drug Conjugate/ADC Related

1964490-09-2

C51H74N8O20

1119.18

N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(=O)C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C2=CC=C(COC(OC3=CC=C(N(=O)=O)C=C3)=O)C=C2

-20°C

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