Mal-N (Me) -C6-N (Me) -PNU-159682 - CAS 2682939-57-5

Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27) is an active molecular conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Mal-N (Me) -C6-N (Me) and the potent cytotoxin PNU-159682. This compound selectively delivers its payload to cells expressing CD46 and releases PNU-159682 through cathepsin B cleavage of the linker, inducing DNA damage and apoptosis. Mal-N (Me) -C6-N (Me) -PNU-159682 has demonstrated sustained tumor regression in patient-derived xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) .

Apoptosis, Drug-Linker Conjugates for ADC

Apoptosis, Antibody-drug Conjugate/ADC Related

2682877

C47H56N4O17

948.964

O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(N(CCCCCCN(C(CN5C(=O)C=CC5=O)=O)C)C)=O)=O)(O)C1)[C@H]6C[C@@]7(N8[C@](O[C@@]7([C@H](C)O6)[H])([C@@H](OC)OCC8)[H])[H]

-20°C

Ice Packs

Small Compound