Mal-va-mac-SN38 - CAS 2778229-31-3

Mal-va-mac-SN38 is a conjugate molecule functioning as an ADC (Antibody-Drug Conjugate) drug-linker. This compound comprises the cytotoxic ADC agent SN-38 and a linker. Once inside the body, Mal-va-mac-SN38 rapidly forms a covalent bond with endogenous albumin, resulting in the formation of HSA-va-mac-SN38. It demonstrates remarkable stability in human plasma and exhibits both antitumor and antimetastatic properties.

Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related

2778229-31-3

C52H61N7O14S

1040.14

C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OCN(C(OCC6=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN7C(=O)C=CC7=O)=O)C(C)C)=O)C)=O)C=C6)=O)CCS(C)(=O)=O)=CC5

-20°C

Ice Packs

Small Compound