Manassantin A - CAS 88497-87-4

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎoB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.

TNF, HIF, NF-κB, cAMP, JNK, MAPK, COX, STAT, ERK, Prostaglandin Receptor

NF-κB, Immunology/Inflammation, Apoptosis, Stem Cells, GPCR/G Protein, Neuroscience, MAPK, JAK/STAT signaling, Chromatin/Epigenetic, Angiogenesis

88406

C42H52O11

732.87

[H][C@@]1(O[C@@]([H])([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1

-20°C

Ice Packs

Natural Product