Manzamine A - CAS 104196-68-1

Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, and decreases tau hyperphosphorylation.

Others, Parasite, HSV, Autophagy, GSK-3, Proton pump, CDK

Autophagy, PI3K/Akt/mTOR signaling, Microbiology/Virology, Membrane transporter/Ion channel, Others, Stem Cells, Cell Cycle/Checkpoint

104127

C36H44N4O

548.775

[H][C@]12C[C@]34C[N@@]5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCCC=C2)c1nccc2c3ccccc3[nH]c12 |w:29.32,c:11,17|

-20°C

Ice Packs

Natural Product