Manzamine A hydrochloride - CAS 104264-80-4

Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM) . Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].

Others, Proton pump, Parasite, HSV, GSK-3, Autophagy, CDK

Microbiology/Virology, Cell Cycle/Checkpoint, Others, PI3K/Akt/mTOR signaling, Autophagy, Stem Cells, Membrane transporter/Ion channel

104180

C36H45ClN4O

585.23

Cl.[H][C@]12C[C@]34CN5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCC\C=C/2)c1nccc2c3ccccc3[nH]c12

-20°C

Ice Packs

Natural Product