MAO-B-IN-45 - CAS 3069915-36-9

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3xTg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.

Microtubule Associated, Monoamine Oxidase, ROS, Glutathione Peroxidase, Beta Amyloid, Ferroptosis

Metabolism, Immunology/Inflammation, Cytoskeletal Signaling, Neuroscience, Apoptosis

3069870

C17H14ClNO3

315.75

O=C1C(O)=CC=2C=CC(OCC3=CC=C(Cl)C=C3)=CC2N1C

-20°C

Ice Packs

Small Compound