MAO-B-IN-46 - CAS 27052-20-6

MAO-B-IN-46 (Compound 16) is a selective human MAO-B inhibitor with an IC50 of 26.8 nM, while showing weaker activity against hMAO-A (IC50: 7.2054 μM) . This compound, also referred to as MAO-B-IN-46 (Compound 8), acts as an α-amylase inhibitor with an IC50 of 19.46 μM. It demonstrates certain neuroprotective properties and exhibits no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS radicals, with IC50 values of 17.86 and 17.71 μM, respectively. MAO-B-IN-46 is applicable in research on neurodegenerative diseases like Parkinson's, diabetes, and conditions related to oxidative stress.

Monoamine Oxidase, Amylase

Neuroscience, Metabolism

27026

C15H9ClO2

256.68

O=C(C=1OC=2C=CC=CC2C1)C3=CC=C(Cl)C=C3

-20°C

Ice Packs

Small Compound