MAPK-IN-5 - CAS 2579683-39-7

MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 μM in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.

ROS, p38 MAPK, Caspase, PARP, Bcl-2 Family, Apoptosis

DNA Damage/DNA Repair, Proteases/Proteasome, Apoptosis, Immunology/Inflammation, Chromatin/Epigenetic, MAPK

2579637

C30H29F3N6O4

594.58

FC(F)(F)C1=CC=C(C=C1)CN2N=NC(=C2)C=3C=CC=C(C3)NC=4N=CN=C5C=C(OCCOC)C(OCCOC)=CC54

-20°C

Ice Packs

Small Compound