Marcfortine A - CAS 75731-43-0

Marcfortine A, an indole alkaloid originally isolated from P. roqueforti, exhibits nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM) . It effectively eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively) . Marcfortine A also dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Parasite, Others

Microbiology/Virology, Others

75688

C28H35N3O4

477.605

CN1C(=O)C23CCCCN2CC11CC2(C(=O)Nc4c2ccc2OC(C)(C)C=COc42)C(C)(C)C1C3

-20°C

Ice Packs

Small Compound