Marizomib - CAS 437742-34-2

Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM.[3]

Proteasome

Ubiquitination, Proteases/Proteasome

437706

0.9941

C15H20ClNO4

313.78

[C@@H](O)([C@]12[C@](C)([C@@H](CCCl)C(=O)N1)OC2=O)[C@]3(CCCC=C3)[H]

-20°C

Ice Packs

Natural Product