MBL-IN-5 - CAS 2876921-34-3

MBL-IN-5 is an inhibitor of metallo-β-lactamase (MBL) . It effectively suppresses three clinically significant B1 subfamily MBLs: NDM-1, VIM-1, and IMP-1 with IC50 values of 0.05 nM, 14 nM, and 21 nM respectively. MBL-IN-5 notably enhances the efficacy of carbapenem antibiotics against MBL-producing clinical strains and, when combined with IPM antibiotics, significantly reduces bacterial load in a thigh infection model.

Beta-lactamase, Antibacterial

Microbiology/Virology

2876884

C20H16ClNO3

353.8

O=C(O)C=1NC=2C=3C=CC=CC3CCC2C1C=4C=C(Cl)C=CC4OC

-20°C

Ice Packs

Small Compound