MC-Gly-Gly-Phe-Gly- (R) -Cyclopropane-Exatecan - CAS 2414254-51-4

MC-Gly-Gly-Phe-Gly- (R) -Cyclopropane-Exatecan is an agent-linker conjugate for antibody-drug conjugates (ADCs), incorporating Exatecan, a DNA Topoisomerase I inhibitor (IC 50 = 2.2 μM) [1].

Topoisomerase, Drug-Linker Conjugates for ADC

DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related

2414199

C55H60FN9O13

1074.12

CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](NC(=O)[C@H](OCNC(=O)CNC(=O)[C@H](Cc6ccccc6)NC(=O)CNC(=O)CNC(=O)CCCCCN6C(=O)C=CC6=O)C6CC6)c(c3Cn1c2=O)c45

-20°C

Ice Packs

Small Compound