Mca-SEVNLDAEFK (Dnp) -NH2 - CAS 1802078-32-5

Mca-SEVNLDAEFK (Dnp) -NH2 is a fluorogenic substrate featuring a 7-methoxycoumarin moiety whose fluorescence is quenched by the adjacent 2,4-dinitrophenyl group through resonance energy transfer. This compound serves as a probe for assessing peptidase activity; enzymatic cleavage of the amide bond separating the fluorophore and quencher results in increased fluorescence. It is particularly useful for quantifying the activity of BACE-1 [1].

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1802078-32-5

C68H89N15O26

1532.52

C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(N)=O)=O)=O)CCC(O)=O)=O)C)=O)CC(O)=O)=O)CC(C)C)=O)CC(N)=O)=O)C(C)C)=O)CCC(O)=O)=O)CO)=O)C=3C=4C(=CC(OC)=CC4)OC(=O)C3

-20°C

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