MCB-22-174 - CAS 3058199-58-6

MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 μM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM) -dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP) .

Others, ERK, Piezo Channel, CaMK

Neuroscience, Others, MAPK, Membrane transporter/Ion channel

3058135

C16H14DCl2N5OS2

429.37

S(C(C1=C(Cl)C=CC=C1Cl)[2H])C=2SC(=NN2)C=3C=NC(NC[C@@H](C)O)=CN3

-20°C

Ice Packs

Small Compound