MDH1/2-IN-1 - CAS 2143473-95-2

MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.

HIF/HIF Prolyl-Hydroxylase, Dehydrogenase, Mitochondrial Metabolism

Chromatin/Epigenetic, Metabolism

2143376

C25H33NO4

411.534

O=C(OC)C=1C=CC=C(C1)NC(=O)CCOC2=CC=C(C=C2)C(C)(C)CC(C)(C)C

-20°C

Ice Packs

Small Compound