MEDS433 - CAS 2241027-61-0

MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM) . MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.

Others, Dehydrogenase

Others, Metabolism

2240966

C20H11F4N3O2

401.31

C(NC1=C(F)C(F)=C(C(F)=C1F)C2=CC=CC=C2)(=O)C3=C4N(NC3=O)C=CC=C4

-20°C

Ice Packs

Small Compound