MEK/PI3K-IN-1 - CAS 2281803-28-7

MEK/PI3K-IN-1 (compound 6r) is a potent dual inhibitor of MEK and PI3K, exhibiting IC50 values of 124 nM for MEK1, 130 nM for PI3Kα, and 236 nM for PI3Kδ. It effectively reduces pAKT and pERK1/2 levels, demonstrating anti-proliferative effects on various tumor cell lines [1].

MEK, Others, PI3K, PERK

PI3K/Akt/mTOR signaling, Others, MAPK, Apoptosis

2281768

C36H37F5IN9O6

913.63

FC(F)c1nc2ccccc2n1-c1nc(NCCOCCOCCOCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)nc(n1)N1CCOCC1

-20°C

Ice Packs

Small Compound