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MEL23 - CAS 642072-49-9

MEL23 - CAS 642072-49-9

MF-0112775-01

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Product Details

  • Bioactivity

    MEL23 is an MDM2E3 ligase inhibitor that prevents the E3 ligase activity of the MDM2-MDMX complex. It inhibits the ubiquitination of Mdm2 and p53 in cells, reducing the viability of wild-type p53 cells. Additionally, MEL23 stabilizes MDM2 through a mechanism independent of p53 transcription.

  • Target

    Ligand for E3 Ligase

  • Related Pathways

    PROTAC

  • CAS Number

    642014

  • Molecular Formula

    C19H22N4O3

  • Molecular Weight

    354.403

  • SMILES

    O=C1NC(=O)C(C(=O)N1CCCC)C2NCCC=3C=4C=CC=CC4NC32

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC